4EB4
Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Thymidylate synthase | polymer | 307 | 35001.0 | 4 | UniProt (P07607) Pfam (PF00303) | Mus musculus (mouse) | TS, TSase |
| 2 | E, M, S, V (A, B, C, D) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
| 3 | F, N, T, W (A, B, C, D) | TOMUDEX | non-polymer | 458.5 | 4 | Chemie (D16) | |||
| 4 | G (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 5 | H, I, J, K, O... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 6 | L (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | R (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 8 | AA, BA, CA, Z (B, C, D, A) | water | water | 18.0 | 1222 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140004.1 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4433.2 | |
| All* | Total formula weight | 144437.2 |
