4EAI
Co-crystal structure of an AMPK core with AMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 106 | 12097.9 | 1 | UniProt (P54645) Pfam (PF16579) In PDB | Rattus norvegicus (Rat) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
2 | B | 5'-AMP-activated protein kinase subunit beta-2 | polymer | 85 | 9886.6 | 1 | UniProt (O43741) Pfam (PF04739) In PDB | Homo sapiens (Human) | AMPK subunit beta-2 |
3 | C | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) In PDB | Rattus norvegicus (Rat) | AMPKg |
4 | C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) | |||
5 | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 394 - 468 (UniProt: P54645)
A: 475 - 494 (UniProt: P54645)
B: 189 - 272 (UniProt: O43741)
PDB | External Database | Details |
---|---|---|
Gly 389 | - | expression tag |
Pro 390 | - | expression tag |
His 391 | - | expression tag |
Met 392 | - | expression tag |
Gly 393 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 469 | - | linker |
Gly 470 | - | linker |
Gly 471 | - | linker |
Gly 472 | - | linker |
Gly 473 | - | linker |
Gly 474 | - | linker |
PDB | External Database | Details |
---|---|---|
Met 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 59418.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1041.7 | |
All* | Total formula weight | 60460.3 |