4EAG
Co-crystal structure of an chimeric AMPK core with ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EG:132E8.2 protein | polymer | 130 | 14897.3 | 1 | UniProt (O18645) Pfam (PF16579) | Drosophila melanogaster (Fruit fly) | FI03728p, SNF1A/AMP-activated protein kinase, SNF1A/AMP-activated protein kinase, isoform A, SNF1A/AMP-activated protein kinase, isoform B, SNF1A/AMP-activated protein kinase, isoform C |
| 2 | B (B) | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 85 | 9794.6 | 1 | UniProt (P80386) Pfam (PF04739) | Rattus norvegicus (rat) | AMPK subunit beta-1, AMPKb, 5'-AMP-activated protein kinase 40 kDa subunit |
| 3 | C (C) | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) | Rattus norvegicus (rat) | AMPK gamma1, AMPK subunit gamma-1, AMPKg |
| 4 | D, E (C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F (C) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 1 | Chemie (TAM) | |||
| 6 | G, H, I (A, B, C) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 458 - 582 (UniProt: O18645)
B: 187 - 270 (UniProt: P80386)
| PDB | External Database | Details |
|---|---|---|
| Gly 453 | - | expression tag |
| Pro 454 | - | expression tag |
| His 455 | - | expression tag |
| Met 456 | - | expression tag |
| Gly 457 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 186 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62126.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1177.6 | |
| All* | Total formula weight | 63303.6 |
