4E5W
JAK1 kinase (JH1 domain) in complex with compound 26
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 2 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 1, JAK-1 |
| 2 | C, E (A, B) | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl][(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | non-polymer | 380.5 | 2 | Chemie (0NT) | |||
| 3 | D (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 421 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69493.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 867.1 | |
| All* | Total formula weight | 70360.3 |
