4E1M
Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HIV-1 Integrase | polymer | 166 | 18404.7 | 1 | UniProt (P12497) Pfam (PF00665) In PDB | Human immunodeficiency virus type 1 (HIV-1) | |
2 | A | (2S)-tert-butoxy[4-(3,4-dimethylphenyl)-2-methylquinolin-3-yl]ethanoic acid | non-polymer | 377.5 | 1 | Chemie (TQ2) | |||
3 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: P12497)
PDB | External Database | Details |
---|---|---|
Gly 47 | - | expression tag |
Ser 48 | - | expression tag |
His 49 | - | expression tag |
Ala 124 | Thr 1271 | conflict |
Lys 185 | Phe 1332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18404.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 377.5 | |
All* | Total formula weight | 18782.2 |