4E05
Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (H) | Thrombin | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (I) | Salivary anti-thrombin peptide anophelin | polymer | 61 | 6542.7 | 1 | UniProt (Q9NJS1) Pfam (PF10731) | Anopheles albimanus (New world malaria mosquito) | |
| 4 | D (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F, G, H (L, H, I) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 40419.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 244.2 | |
| All* | Total formula weight | 40663.6 |
