4DOH

IL20/IL201/IL20R2 Ternary Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, C)	Interleukin-20	polymer	153	17626.5	2	UniProt (Q9NYY1) Pfam (PF00726)	Homo sapiens (human)	IL-20, Cytokine Zcyto10
2	B, E (B, D)	Interleukin-20 receptor subunit beta	polymer	206	23047.0	2	UniProt (Q6UXL0) Pfam (PF01108) Pfam (PF09294)	Homo sapiens (human)	IL-20 receptor subunit beta, IL-20R-beta, IL-20RB, IL-20R2
3	C, F (R, E)	Interleukin-20 receptor subunit alpha	polymer	221	25270.7	2	UniProt (Q9UHF4) Pfam (PF01108) Pfam (PF09294)	Homo sapiens (human)	IL-20 receptor subunit alpha, IL-20R-alpha, IL-20RA, Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, CRF2-8, IL-20R1, ZcytoR7
4	G, H, I, J, K (B, R, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
5	L, M, N, O, P... (A, B, R, C, D...)	water	water		18.0	57	Chemie (HOH)

Sequence modifications

A, C: 25 - 176 (UniProt: Q9NYY1)

PDB	External Database	Details
Ala 24	-	expression tag

B, D: 30 - 231 (UniProt: Q6UXL0)

PDB	External Database	Details
Ala 29	-	expression tag
Gln 40	Asn 40	engineered mutation
Gln 134	Asn 134	engineered mutation
Glu 232	-	expression tag
Gly 233	-	expression tag
Arg 234	-	expression tag

R, E: 29 - 245 (UniProt: Q9UHF4)

PDB	External Database	Details
Arg 111	Lys 111	engineered mutation
Arg 113	Lys 113	engineered mutation
Ile 246	-	expression tag
Glu 247	-	expression tag
Gly 248	-	expression tag
Arg 249	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	131888.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	132994.6

*Water molecules are not included.