4DL7
Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (Pt-GG4).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase eta | polymer | 435 | 48617.7 | 1 | UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) | Homo sapiens (human) | RAD30 homolog A, Xeroderma pigmentosum variant type protein |
| 2 | B (T) | DNA (5'-D(*TP*AP*CP*TP*CP*GP*GP*TP*CP*AP*CP*T)-3') | polymer | 12 | 3613.4 | 1 | |||
| 3 | C (P) | DNA (5'-D(*TP*AP*GP*TP*GP*AP*CP*CP*G)-3') | polymer | 9 | 2755.8 | 1 | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 490.2 | 1 | Chemie (DZ4) | |||
| 6 | F (T) | Cisplatin | non-polymer | 300.0 | 1 | Chemie (CPT) | |||
| 7 | G, H (A, T) | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 54986.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 882.3 | |
| All* | Total formula weight | 55869.2 |
