4DKF

Crystal Structure of Human Interleukin-34 Bound to FAb2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-34	polymer	190	21860.8	2	UniProt (Q6ZMJ4) Pfam (PF15036)	Homo sapiens (human)	IL-34
2	C, E (H, I)	FAb2 Heavy Chain	polymer	226	23764.4	2		Homo sapiens (human)
3	D, F (L, M)	FAb2 Light Chain	polymer	214	23342.9	2		Homo sapiens (human)
4	G, H (C, D)	alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G08748CW)
5	I, J, K, L, M... (A, B, H, L, I...)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 21 - 193 (UniProt: Q6ZMJ4)

PDB	External Database	Details
Ala 18	-	expression tag
Gly 19	-	expression tag
Ser 20	-	expression tag
Gly 194	-	expression tag
Asn 195	-	expression tag
Ser 196	-	expression tag
Gly 197	-	expression tag
Asn 198	-	expression tag
Ser 199	-	expression tag
Asp 200	-	expression tag
Tyr 201	-	expression tag
Lys 202	-	expression tag
Asp 203	-	expression tag
Asp 204	-	expression tag
Asp 205	-	expression tag
Asp 206	-	expression tag
Lys 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	137936.2
Branched	Number of molecules	2
	Total formula weight	1821.6
All*	Total formula weight	139757.9

*Water molecules are not included.