4DK8
Crystal structure of LXR ligand binding domain in complex with partial agonist 5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Oxysterols receptor LXR-beta | polymer | 247 | 28528.8 | 2 | UniProt (P55055) Pfam (PF00104) In PDB | Homo sapiens (human) | Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor |
| 2 | B, D | Nuclear receptor coactivator 1 | polymer | 12 | 1531.7 | 2 | UniProt (Q15788) In PDB | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | A, C | N-methyl-N-(4-{(1S)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide | non-polymer | 468.5 | 2 | Chemie (0KT) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | A, C | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 6 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, C: 219 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Ser 216 | - | expression tag |
| His 217 | - | expression tag |
| Met 218 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60121.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1236.5 | |
| All* | Total formula weight | 61357.5 |
