4DJQ
Crystal Structure of wild-type HIV-1 Protease in Complex with MKP86
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Pol polyprotein | polymer | 99 | 10815.8 | 2 | UniProt (Q90K99) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | HIV-1 Protease |
| 2 | A | 2-(2-oxoimidazolidin-1-yl)ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate | non-polymer | 576.7 | 1 | Chemie (M86) | |||
| 3 | B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 196 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q90K99)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 766.6 | |
| All* | Total formula weight | 22398.2 |
