4DIT
Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycogen synthase kinase-3 beta | polymer | 382 | 43330.5 | 1 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta, Serine/threonine-protein kinase GSK3B |
| 2 | B (A) | N-(pyridin-3-yl)-2-(thiophen-3-yl)-3H-imidazo[4,5-b]pyridine-7-carboxamide | non-polymer | 321.4 | 1 | Chemie (0KD) | |||
| 3 | C (A) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 27 - 393 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Ala 394 | - | expression tag |
| Ala 395 | - | expression tag |
| Ala 396 | - | expression tag |
| Leu 397 | - | expression tag |
| Glu 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43330.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 321.4 | |
| All* | Total formula weight | 43651.9 |
