4DEI

Crystal structure of c-Met in complex with triazolopyridinone inhibitor 24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	309	35215.7	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (human)	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
2	A	3-{(1S)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl}-5-(3-methyl-1,2-thiazol-5-yl)-3,5-dihydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one	non-polymer		462.5	1	Chemie (0JL)
3		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A: 1048 - 1351 (UniProt: P08581)

PDB	External Database	Details
His 1352	-	expression tag
His 1353	-	expression tag
His 1354	-	expression tag
His 1355	-	expression tag
His 1356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35215.7
Non-Polymers*	Number of molecules	1
	Total formula weight	462.5
All*	Total formula weight	35678.2

*Water molecules are not included.