4DCP

Crystal Structure of caspase 3, L168F mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Caspase-3 subunit p17	polymer	147	16673.9	2	UniProt (P42574) Pfam (PF00656) In PDB	Homo sapiens (human)
2	B, E	Caspase-3 subunit p12	polymer	108	12739.5	2	UniProt (P42574) Pfam (PF00656) In PDB	Homo sapiens (human)
3	C, F	Caspase Inhibitor AC-DEVD-CHO	polymer	5	488.5	2	BIRD (PRD_000422)
4		water	water		18.0	369	Chemie (HOH)

Sequence modifications

A, D: 29 - 175 (UniProt: P42574)

PDB	External Database	Details
Phe 168	Leu 168	ENGINEERED MUTATION

B, E: 176 - 277 (UniProt: P42574)

PDB	External Database	Details
His 278	-	EXPRESSION TAG
His 279	-	EXPRESSION TAG
His 280	-	EXPRESSION TAG
His 281	-	EXPRESSION TAG
His 282	-	EXPRESSION TAG
His 283	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	59803.8
All*	Total formula weight	59803.8

*Water molecules are not included.