4DCJ

Crystal structure of caspase 3, L168D mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Caspase-3 subunit p17	polymer	147	16641.8	2	UniProt (P42574) Pfam (PF00656)	Homo sapiens (human)
2	B, E (B, E)	Caspase-3 subunit p12	polymer	108	12739.5	2	UniProt (P42574) Pfam (PF00656)	Homo sapiens (human)
3	C, F (C, F)	Caspase Inhibitor AC-DEVD-CHO	polymer	5	488.5	2	BIRD (PRD_000422)
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	390	Chemie (HOH)

Sequence modifications

A, D: 29 - 175 (UniProt: P42574)

PDB	External Database	Details
Asp 168	Leu 168	engineered mutation

B, E: 176 - 277 (UniProt: P42574)

PDB	External Database	Details
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	59739.6
All*	Total formula weight	59739.6

*Water molecules are not included.