4DCE
Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ALK tyrosine kinase receptor | polymer | 333 | 37568.1 | 2 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | C, D (A, B) | (3S)-N-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | non-polymer | 491.6 | 2 | Chemie (0JF) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B: 1078 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 1097 | Cys 1097 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75136.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 983.2 | |
| All* | Total formula weight | 76119.4 |
