4DC2

Structure of PKC in Complex with a Substrate Peptide from Par-3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein kinase C iota type	polymer	396	45697.2	1	UniProt (Q62074) Pfam (PF00069) Pfam (PF00433)	Mus musculus (mouse)	PKC, Atypical protein kinase C-lambda/iota, aPKC-lambda/iota, nPKC-iota
2	B (Z)	Partitioning defective 3 homolog	polymer	28	3207.6	1	UniProt (Q9Z340)	Rattus norvegicus	PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, Atypical PKC-specific-binding protein, ASBP
3	C (A)	ADENINE	non-polymer		135.1	1	Chemie (ADE)
4	D, E (A, Z)	water	water		18.0	52	Chemie (HOH)

Sequence modifications

A: 222 - 586 (UniProt: Q62074)

PDB	External Database	Details
Met 191	-	expression tag
Ser 192	-	expression tag
Tyr 193	-	expression tag
Tyr 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
Asp 201	-	expression tag
Tyr 202	-	expression tag
Asp 203	-	expression tag
Ile 204	-	expression tag
Pro 205	-	expression tag
Thr 206	-	expression tag
Thr 207	-	expression tag
Glu 208	-	expression tag
Asn 209	-	expression tag
Leu 210	-	expression tag
Tyr 211	-	expression tag
Phe 212	-	expression tag
Gln 213	-	expression tag
Gly 214	-	expression tag
Ala 215	-	expression tag
Met 216	-	expression tag
Gly 217	-	expression tag
Ser 218	-	expression tag
Gly 219	-	expression tag
Ile 220	-	expression tag
Glu 221	-	expression tag
Arg 273	Lys 282	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48904.8
Non-Polymers*	Number of molecules	1
	Total formula weight	135.1
All*	Total formula weight	49039.9

*Water molecules are not included.