4DBU
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aldo-keto reductase family 1 member C3 | polymer | 323 | 36896.2 | 2 | UniProt (P42330) Pfam (PF00248) | Homo sapiens (human) | 17-beta-hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 3-alpha-HSD type II, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type 2, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, DD-3, DD3, Dihydrodiol dehydrogenase type I, HA1753, Indanol dehydrogenase, Prostaglandin F synthase, PGFS, Testosterone 17-beta-dehydrogenase 5, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, F (A, B) | 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid | non-polymer | 281.2 | 2 | Chemie (BT9) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 323 (UniProt: P42330)
| PDB | External Database | Details |
|---|---|---|
| Gln 5 | His 5 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73792.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2049.3 | |
| All* | Total formula weight | 75841.7 |
