4DBN
Crystal Structure of the Kinase domain of Human B-raf with a [1,3]thiazolo[5,4-b]pyridine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 284 | 32322.4 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | non-polymer | 548.0 | 2 | Chemie (0JA) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 444 - 725 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 442 | - | expression tag |
| Ser 443 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64644.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1096.0 | |
| All* | Total formula weight | 65740.7 |
