4DAJ

Structure of the M3 Muscarinic Acetylcholine Receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Muscarinic acetylcholine receptor M3, Lysozyme	polymer	479	54990.3	4	UniProt (P08483) UniProt (P00720) Pfam (PF00001) Pfam (PF00959)	Rattus norvegicus (brown rat rat rats)	Endolysin, Lysis protein, Muramidase
2	E, J, L, O (A, B, C, D)	(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane	non-polymer		392.5	4	Chemie (0HK)
3	F, G, H, I, K... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	10	Chemie (PO4)

Sequence modifications

A, B, C, D: 57 - 259 (UniProt: P08483)

PDB	External Database	Details
Gly 56	-	expression tag

A, B, C, D: 1001 - 1161 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A, B, C, D: 482 - 589 (UniProt: P08483)

PDB	External Database	Details
His 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	219961.2
Non-Polymers*	Number of molecules	14
	Total formula weight	2519.8
All*	Total formula weight	222480.9

*Water molecules are not included.