4D9U
Rsk2 C-terminal Kinase Domain, (E)-tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ribosomal protein S6 kinase alpha-3 | polymer | 342 | 38478.9 | 1 | UniProt (P51812) Pfam (PF00069) | Homo sapiens (human) | S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2 |
| 2 | B (A) | tert-butyl (2S)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanopropanoate | non-polymer | 435.5 | 1 | Chemie (0JH) | |||
| 3 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | D (A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 399 - 740 (UniProt: P51812)
| PDB | External Database | Details |
|---|---|---|
| Glu 591 | Lys 591 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38478.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 458.5 | |
| All* | Total formula weight | 38937.4 |
