4D8P
Structural and functional studies of the trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) molecule
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | HLA-DQA1 protein | polymer | 213 | 23854.6 | 2 | UniProt (L8E864) Pfam (PF00993) Pfam (PF07654) In PDB | Homo sapiens (Human) | MHC class II antigen |
2 | B, D | Peptide from Gamma-gliadin,HLA class II histocompatibility antigen, DQ beta 1 chain | polymer | 250 | 28065.3 | 2 | UniProt (Q94G94) UniProt (Q5Y7D3) Pfam (PF00969) Pfam (PF07654) In PDB | Triticum aestivum (Wheat) | MHC class II antigen |
3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, C: 0 - 191 (UniProt: L8E864)
B, D: -29 - -15 (UniProt: Q94G94)
B, D: 1 - 198 (UniProt: Q5Y7D3)
PDB | External Database | Details |
---|---|---|
Gly 192 | - | expression tag |
Gly 193 | - | expression tag |
Gly 194 | - | expression tag |
Ser 195 | - | expression tag |
Gly 196 | - | expression tag |
Gly 197 | - | expression tag |
Gly 198 | - | expression tag |
Ser 199 | - | expression tag |
Cys 200 | - | expression tag |
Ser 201 | - | expression tag |
Arg 202 | - | expression tag |
Gly 203 | - | expression tag |
Gly 204 | - | expression tag |
Leu 205 | - | expression tag |
Glu 206 | - | expression tag |
Val 207 | - | expression tag |
Leu 208 | - | expression tag |
Phe 209 | - | expression tag |
Gln 210 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Arg -33 | - | expression tag |
Asp -32 | - | expression tag |
Ser -31 | - | expression tag |
Gly -30 | - | expression tag |
Glu -26 | Gln 71 | engineered mutation |
Glu -23 | Gln 74 | engineered mutation |
Gly -14 | - | linker |
Ala -13 | - | linker |
Gly -12 | - | linker |
Ser -11 | - | linker |
Leu -10 | - | linker |
Val -9 | - | linker |
Pro -8 | - | linker |
Arg -7 | - | linker |
Gly -6 | - | linker |
Ser -5 | - | linker |
Gly -4 | - | linker |
Gly -3 | - | linker |
Gly -2 | - | linker |
Gly -1 | - | linker |
Ser 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 199 | - | expression tag |
Gly 200 | - | expression tag |
Gly 201 | - | expression tag |
Ser 202 | - | expression tag |
Gly 203 | - | expression tag |
Gly 204 | - | expression tag |
Gly 205 | - | expression tag |
Ser 206 | - | expression tag |
Cys 207 | - | expression tag |
Ser 208 | - | expression tag |
Arg 209 | - | expression tag |
Gly 210 | - | expression tag |
Gly 211 | - | expression tag |
Leu 212 | - | expression tag |
Glu 213 | - | expression tag |
Val 214 | - | expression tag |
Leu 215 | - | expression tag |
Phe 216 | - | expression tag |
Gln 217 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 103839.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 184.2 | |
All* | Total formula weight | 104023.9 |