4D8P
Structural and functional studies of the trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) molecule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HLA-DQA1 protein | polymer | 213 | 23854.6 | 2 | UniProt (L8E864) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (Human) | MHC class II antigen |
| 2 | B, D (B, D) | Peptide from Gamma-gliadin,HLA class II histocompatibility antigen, DQ beta 1 chain | polymer | 250 | 28065.3 | 2 | UniProt (Q94G94) UniProt (Q5Y7D3) Pfam (PF00969) Pfam (PF07654) | Triticum aestivum (Wheat) | MHC class II antigen |
| 3 | E, F (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, C: 0 - 191 (UniProt: L8E864)
B, D: -29 - -15 (UniProt: Q94G94)
B, D: 1 - 198 (UniProt: Q5Y7D3)
| PDB | External Database | Details |
|---|---|---|
| Gly 192 | - | expression tag |
| Gly 193 | - | expression tag |
| Gly 194 | - | expression tag |
| Ser 195 | - | expression tag |
| Gly 196 | - | expression tag |
| Gly 197 | - | expression tag |
| Gly 198 | - | expression tag |
| Ser 199 | - | expression tag |
| Cys 200 | - | expression tag |
| Ser 201 | - | expression tag |
| Arg 202 | - | expression tag |
| Gly 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Leu 205 | - | expression tag |
| Glu 206 | - | expression tag |
| Val 207 | - | expression tag |
| Leu 208 | - | expression tag |
| Phe 209 | - | expression tag |
| Gln 210 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Arg -33 | - | expression tag |
| Asp -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Gly -30 | - | expression tag |
| Glu -26 | Gln 71 | engineered mutation |
| Glu -23 | Gln 74 | engineered mutation |
| Gly -14 | - | linker |
| Ala -13 | - | linker |
| Gly -12 | - | linker |
| Ser -11 | - | linker |
| Leu -10 | - | linker |
| Val -9 | - | linker |
| Pro -8 | - | linker |
| Arg -7 | - | linker |
| Gly -6 | - | linker |
| Ser -5 | - | linker |
| Gly -4 | - | linker |
| Gly -3 | - | linker |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Gly 200 | - | expression tag |
| Gly 201 | - | expression tag |
| Ser 202 | - | expression tag |
| Gly 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Gly 205 | - | expression tag |
| Ser 206 | - | expression tag |
| Cys 207 | - | expression tag |
| Ser 208 | - | expression tag |
| Arg 209 | - | expression tag |
| Gly 210 | - | expression tag |
| Gly 211 | - | expression tag |
| Leu 212 | - | expression tag |
| Glu 213 | - | expression tag |
| Val 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Phe 216 | - | expression tag |
| Gln 217 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 103839.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 184.2 | |
| All* | Total formula weight | 104023.9 |
