4D35
Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(3- fluorophenyl)propan-1-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | NITRIC OXIDE SYNTHASE, ENDOTHELIAL | polymer | 443 | 49727.0 | 2 | UniProt (P29473) Pfam (PF02898) In PDB | BOS TAURUS (CATTLE) | CONSTITUTIVE NOS, CNOS, EC-NOS, ENDOTHELIAL NOS, ENOS, NOS TYPE III, NOSIII, ENDOTHELIAL NITRIC OXIDE SYNTHASE |
| 2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | A, B | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | A, B | 3-(3-fluorophenyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}propan-1-amine | non-polymer | 325.4 | 2 | Chemie (4E8) | |||
| 5 | A, B | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 6 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A, B: 40 - 482 (UniProt: P29473)
| PDB | External Database | Details |
|---|---|---|
| Arg 100 | Cys 100 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 99454.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2852.0 | |
| All* | Total formula weight | 102306.0 |
