4D1N

Structure of human nNOS heme domain with L-Arg bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	NITRIC OXIDE SYNTHASE, BRAIN	polymer	420	48655.3	4	UniProt (P29475) Pfam (PF02898) In PDB	HOMO SAPIENS (HUMAN)	CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N-NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, BNOS, NEURONAL NITRIC OXIDE SYNTHASE
2	A, B, C, D	ARGININE	non-polymer		175.2	4	Chemie (ARG)
3	A, B, C, D	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
4	A, B, C, D	5,6,7,8-TETRAHYDROBIOPTERIN	non-polymer		241.2	4	Chemie (H4B)
5	A, B, C, D	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
6	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7		water	water		18.0	856	Chemie (HOH)

Sequence modifications

A, B, C, D: 302 - 721 (UniProt: P29475)

PDB	External Database	Details
Ala 354	Arg 354	engineered mutation
Asp 357	Gly 357	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	194621.3
Non-Polymers*	Number of molecules	21
	Total formula weight	4907.2
All*	Total formula weight	199528.5

*Water molecules are not included.