4D18

Crystal structure of the COP9 signalosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I (A, I)	COP9 SIGNALOSOME COMPLEX SUBUNIT 1	polymer	480	54222.8	2	UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151)	HOMO SAPIENS (HUMAN)	SGN1, SIGNALOSOME SUBUNIT 1, G PROTEIN PATHWAY SUPPRESSOR 1, GPS-1, JAB1-CONTAINING SIGNALOSOME SUBUNIT 1, PROTEIN MFH
2	B, J (B, J)	COP9 SIGNALOSOME COMPLEX SUBUNIT 2	polymer	447	51992.9	2	UniProt (P61201) Pfam (PF01399)	HOMO SAPIENS (HUMAN)	SGN2, SIGNALOSOME SUBUNIT 2, ALIEN HOMOLOG, JAB1-CONTAINING SIGNALOSOME SUBUNIT 2, THYROID RECEPTOR-INTERACTING PROTEIN 15, TR-INTERACTING PROTEIN 15, TRIP-15
3	C, K (C, K)	COP9 SIGNALOSOME COMPLEX SUBUNIT 3	polymer	427	48252.4	2	UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215)	HOMO SAPIENS (HUMAN)	SGN3, SIGNALOSOME SUBUNIT 3, JAB1-CONTAINING SIGNALOSOME SUBUNIT 3
4	D, L (D, L)	COP9 SIGNALOSOME COMPLEX SUBUNIT 4	polymer	410	46651.0	2	UniProt (Q9BT78) Pfam (PF18420) Pfam (PF22241) Pfam (PF01399)	HOMO SAPIENS (HUMAN)	SGN4, SIGNALOSOME SUBUNIT 4, JAB1-CONTAINING SIGNALOSOME SUBUNIT 4
5	E, M (E, M)	COP9 SIGNALOSOME COMPLEX SUBUNIT 5	polymer	327	36928.9	2	UniProt (Q92905) Pfam (PF01398) Pfam (PF18323)	HOMO SAPIENS (HUMAN)	SGN5, SIGNALOSOME SUBUNIT 5, JUN ACTIVATION DOMAIN-BINDING PROTEIN 1
6	F, N (F, N)	COP9 SIGNALOSOME COMPLEX SUBUNIT 6	polymer	331	36531.7	2	UniProt (Q7L5N1) Pfam (PF01398) Pfam (PF13012)	HOMO SAPIENS (HUMAN)	SGN6, SIGNALOSOME SUBUNIT 6, JAB1-CONTAINING SIGNALOSOME SUBUNIT 6, MOV34 HOMOLOG, VPR-INTERACTING PROTEIN, HVIP
7	G, O (G, O)	COP9 SIGNALOSOME COMPLEX SUBUNIT 7A	polymer	222	24649.2	2	UniProt (Q9UBW8) Pfam (PF22061) Pfam (PF01399) Pfam (PF18392)	HOMO SAPIENS (HUMAN)	SGN7A, SIGNALOSOME SUBUNIT 7A, DERMAL PAPILLA-DERIVED PROTEIN 10, JAB1-CONTAINING SIGNALOSOME SUBUNIT 7A
8	H, P (H, P)	COP9 SIGNALOSOME COMPLEX SUBUNIT 8	polymer	213	23573.9	2	UniProt (Q99627) Pfam (PF10075)	HOMO SAPIENS (HUMAN)	SGN8, SIGNALOSOME SUBUNIT 8, COP9 HOMOLOG, HCOP9, JAB1-CONTAINING SIGNALOSOME SUBUNIT 8
9	Q, R (E, M)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, I: 52 - 527 (UniProt: Q13098)

PDB	External Database	Details
Gly 48	-	expression tag
Gly 49	-	expression tag
Gly 50	-	expression tag
Arg 51	-	expression tag

B, J: 1 - 443 (UniProt: P61201)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

C, K: 1 - 423 (UniProt: Q9UNS2)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

D, L: 1 - 406 (UniProt: Q9BT78)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

E, M: 12 - 334 (UniProt: Q92905)

PDB	External Database	Details
Gly 8	-	expression tag
Gly 9	-	expression tag
Gly 10	-	expression tag
Arg 11	-	expression tag

F, N: 1 - 327 (UniProt: Q7L5N1)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

G, O: 1 - 218 (UniProt: Q9UBW8)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

H, P: 1 - 209 (UniProt: Q99627)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	645605.7
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	645736.5

*Water molecules are not included.