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4D0X

Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ATYROSINE-PROTEIN KINASE JAK2polymer29835198.01UniProt (O60674)
Pfam (PF07714)
In PDB
HOMO SAPIENS (HUMAN)JANUS KINASE 2, JAK-2
2A5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamidenon-polymer381.71Chemie (953)
3AGLYCEROLnon-polymer92.11Chemie (GOL)
4waterwater18.0225Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight35198.0
Non-Polymers*Number of molecules2
Total formula weight473.8
All*Total formula weight35671.8
*Water molecules are not included.

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PDB entries from 2024-03-27

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