4D0X
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TYROSINE-PROTEIN KINASE JAK2 | polymer | 298 | 35198.0 | 1 | UniProt (O60674) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | JANUS KINASE 2, JAK-2 |
| 2 | B (A) | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | non-polymer | 381.7 | 1 | Chemie (953) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35198.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 473.8 | |
| All* | Total formula weight | 35671.8 |
