4CXW

Crystal structure of human FTO in complex with subfamily-selective inhibitor 12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO	polymer	495	56823.0	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB	HOMO SAPIENS (HUMAN)	FAT MASS AND OBESITY-ASSOCIATED PROTEIN
2	A	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
3	A	(2E)-4-[N'-(4-benzyl-pyridine-3-carbonyl)-hydrazino]-4-oxo-but-2-enoic acid	non-polymer		325.3	1	Chemie (6MK)
4		water	water		18.0	65	Chemie (HOH)

Sequence modifications

A: 32 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
Met 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56823.0
Non-Polymers*	Number of molecules	2
	Total formula weight	384.0
All*	Total formula weight	57207.1

*Water molecules are not included.