4CQL

Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E, H, I...	ESTRADIOL 17-BETA-DEHYDROGENASE 8	polymer	261	26999.7	8	UniProt (Q92506) Pfam (PF13561) In PDB	HOMO SAPIENS (HUMAN)	3-KETOACYL REDUCTASE ALPHA SUBUNIT, 1 7-BETA-HYDROXYSTEROID D 17-BETA-HSD 8,3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, PROTEIN KE6, KE-6, REALLY INTERESTING NEW GENE 2 PROTEIN, TESTOSTERONE 17-BETA-DEHYDROGENASE 8
2	B, C, F, G, J...	CARBONYL REDUCTASE FAMILY MEMBER 4	polymer	244	26298.5	8	UniProt (Q8N4T8) Pfam (PF13561) In PDB	HOMO SAPIENS (HUMAN)	3-KETOACYL REDUCTASE BETA SUBUNIT, QUINONE REDUCTASE CBR4
3	A, D, E, H, I...	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	8	Chemie (NAD)
4		water	water		18.0	218	Chemie (HOH)

Sequence modifications

B, C, F, G, J, K, N, O: 1 - 237 (UniProt: Q8N4T8)

PDB	External Database	Details
Met -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	426386.0
Non-Polymers*	Number of molecules	8
	Total formula weight	5307.4
All*	Total formula weight	431693.4

*Water molecules are not included.