4CQE
B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | SLC45A3-BRAF FUSION PROTEIN | polymer | 278 | 31613.2 | 2 | UniProt (D7PBN4) Pfam (PF07714) UniProt (by SIFTS) (P15056) In PDB | HOMO SAPIENS (HUMAN) | SERINE THREONINE-PROTEIN KINASE B-RAF |
2 | A, B | N-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide | non-polymer | 627.7 | 2 | Chemie (CQE) | |||
3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, B: 448 - 723 (UniProt: D7PBN4)
PDB | External Database | Details |
---|---|---|
Gly 446 | - | expression tag |
Pro 447 | - | expression tag |
Ala 543 | Ile 106 | engineered mutation |
Ser 544 | Ile 107 | engineered mutation |
Lys 551 | Ile 114 | engineered mutation |
Arg 562 | Gln 125 | engineered mutation |
Asn 588 | Leu 151 | engineered mutation |
Glu 600 | Val 163 | engineered mutation |
Ser 630 | Lys 193 | engineered mutation |
Glu 667 | Phe 230 | engineered mutation |
Ser 673 | Tyr 236 | engineered mutation |
Arg 688 | Ala 251 | engineered mutation |
Ser 706 | Leu 269 | engineered mutation |
Arg 709 | Gln 272 | engineered mutation |
Glu 713 | Ser 276 | engineered mutation |
Glu 716 | Leu 279 | engineered mutation |
Glu 720 | Ser 283 | engineered mutation |
Ser 722 | Pro 285 | engineered mutation |
Gly 723 | Lys 286 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 63226.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1255.4 | |
All* | Total formula weight | 64481.9 |