4COF

Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (A, B, C, D, E)	GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3	polymer	355	40832.0	5	UniProt (P28472) Pfam (PF02931) Pfam (PF02932)	HOMO SAPIENS (HUMAN)	GABA(A) RECEPTOR SUBUNIT BETA-3, GABA RECEPTOR, IONOTROPIC, BETA-3
2	F, G, H, I, J (F, G, H, I, J)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	5	In PDB GlyTouCan (G15407YE)
3	K, O, R, U, X (A, B, C, D, E)	BENZAMIDINE	non-polymer		120.2	5	Chemie (BEN)
4	L, N, Q, T, W... (A, B, C, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
5	M, P, S, V, Y (A, B, C, D, E)	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)

Sequence modifications

A, B, C, D, E: 1 - 307 (UniProt: P28472)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Gly 449	-	expression tag
Ala 450	-	expression tag
Thr 451	-	expression tag
Glu 452	-	expression tag
Thr 453	-	expression tag
Ser 454	-	expression tag
Gln 455	-	expression tag
Val 456	-	expression tag
Ala 457	-	expression tag
Pro 458	-	expression tag
Ala 459	-	expression tag

A, B, C, D, E: 422 - 448 (UniProt: P28472)

PDB	External Database	Details
Ser 308	-	linker
Gln 309	-	linker
Pro 310	-	linker
Ala 311	-	linker
Arg 312	-	linker
Ala 313	-	linker
Ala 314	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	204159.8
Branched	Number of molecules	5
	Total formula weight	2932.7
Non-Polymers*	Number of molecules	16
	Total formula weight	2105.3
All*	Total formula weight	209197.8

*Water molecules are not included.