4COF
Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 | polymer | 355 | 40832.0 | 5 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | HOMO SAPIENS (HUMAN) | GABA(A) RECEPTOR SUBUNIT BETA-3, GABA RECEPTOR, IONOTROPIC, BETA-3 |
2 | F, G, H, I, J | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
3 | A, B, C, D, E | BENZAMIDINE | non-polymer | 120.2 | 5 | Chemie (BEN) | |||
4 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
5 | A, B, C, D, E | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) |
Sequence modifications
A, B, C, D, E: 1 - 307 (UniProt: P28472)
A, B, C, D, E: 422 - 448 (UniProt: P28472)
PDB | External Database | Details |
---|---|---|
Glu -2 | - | expression tag |
Thr -1 | - | expression tag |
Gly 0 | - | expression tag |
Gly 449 | - | expression tag |
Ala 450 | - | expression tag |
Thr 451 | - | expression tag |
Glu 452 | - | expression tag |
Thr 453 | - | expression tag |
Ser 454 | - | expression tag |
Gln 455 | - | expression tag |
Val 456 | - | expression tag |
Ala 457 | - | expression tag |
Pro 458 | - | expression tag |
Ala 459 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 308 | - | linker |
Gln 309 | - | linker |
Pro 310 | - | linker |
Ala 311 | - | linker |
Arg 312 | - | linker |
Ala 313 | - | linker |
Ala 314 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 204159.8 | |
Branched | Number of molecules | 5 |
Total formula weight | 2932.7 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 2105.3 | |
All* | Total formula weight | 209197.8 |