4CNH

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ALK TYROSINE KINASE RECEPTOR	polymer	327	36909.4	2	UniProt (Q9UM73) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	ANAPLASTIC LYMPHOMA KINASE, ANAPLASTIC LYMPHOMA KINASE
2	A, B	3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine	non-polymer		343.4	3	Chemie (3U9)
3		water	water		18.0	316	Chemie (HOH)

Sequence modifications

A, B: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1085	-	expression tag
Ala 1086	-	expression tag
His 1087	-	expression tag
His 1088	-	expression tag
His 1089	-	expression tag
His 1090	-	expression tag
His 1091	-	expression tag
His 1092	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73818.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1030.1
All*	Total formula weight	74848.8

*Water molecules are not included.