4CNH
Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ALK TYROSINE KINASE RECEPTOR | polymer | 327 | 36909.4 | 2 | UniProt (Q9UM73) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, ANAPLASTIC LYMPHOMA KINASE |
| 2 | C, D, E (A, B) | 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine | non-polymer | 343.4 | 3 | Chemie (3U9) | |||
| 3 | F, G (A, B) | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence modifications
A, B: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73818.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1030.1 | |
| All* | Total formula weight | 74848.8 |
