4CN3

Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Gde1SpA Response Element

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	RETINOIC ACID RECEPTOR RXR-ALPHA	polymer	87	10262.9	3	UniProt (P19793) Pfam (PF00105)	HOMO SAPIENS (HUMAN)	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 1, RETINOID X RECEPTOR ALPHA
2	D (D)	RETINOIC ACID RECEPTOR RXR-ALPHA	polymer	87	10263.9	1	UniProt (P19793) Pfam (PF00105)	HOMO SAPIENS (HUMAN)	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 1, RETINOID X RECEPTOR ALPHA
3	E, G (E, G)	5'-D(*CP*TP*AP*GP*TP*TP*CP*AP*AP*AP*GP*TP*TP*CP *AP*CP*A)-3'	polymer	17	5170.4	2		HOMO SAPIENS
4	F, H (F, H)	5'-D(*TP*GP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*AP*CP *TP*AP*G)-3'	polymer	17	5241.4	2		HOMO SAPIENS
5	I, J, K, L, M... (A, B, C, D)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
6	Q, R, S, T, U... (A, B, C, D, E...)	water	water		18.0	323	Chemie (HOH)

Sequence modifications

A, B, C: 130 - 212 (UniProt: P19793)

PDB	External Database	Details
Gly 126	-	expression tag
Ser 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

D: 130 - 212 (UniProt: P19793)

PDB	External Database	Details
Gly 126	-	expression tag
Ser 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag
Asp 174	Asn 77	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	61876.3
Non-Polymers*	Number of molecules	8
	Total formula weight	523.3
All*	Total formula weight	62399.6

*Water molecules are not included.