4CMT
Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK TYROSINE KINASE RECEPTOR | polymer | 327 | 36909.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, CD246 |
| 2 | A | 3-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine | non-polymer | 455.5 | 1 | Chemie (GWH) | |||
| 3 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36909.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 455.5 | |
| All* | Total formula weight | 37364.9 |
