4CI1
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA DAMAGE-BINDING PROTEIN 1 | polymer | 1158 | 129493.9 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | HOMO SAPIENS (HUMAN) | DDB P127 SUBUNIT, DNA DAMAGE-BINDING PROTEIN A, DDBA, DAMAGE-SPECIFIC DNA-BINDING PROTEIN 1, HBV X-ASSOCIATED PROTEIN 1, XAP-1, UV-DAMAGED DNA-BINDING FACTOR, UV-DAMAGED DNA-BINDING PROTEIN 1, UV-DDB 1, XPE-BINDING FACTOR, XPE-BF, XERODERMA PIGMENTOSUM GROUP E-COMPLEMENTING PROTEIN, XPCE |
| 2 | B (B) | PROTEIN CEREBLON | polymer | 469 | 54207.1 | 1 | UniProt (P0CF65) Pfam (PF02190) Pfam (PF03226) | GALLUS GALLUS (CHICKEN) | |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (B) | S-Thalidomide | non-polymer | 258.2 | 1 | Chemie (EF2) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 1 - 1140 (UniProt: Q16531)
B: 1 - 445 (UniProt: P0CF65)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Arg -10 | - | expression tag |
| Arg -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Val -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Arg -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Trp -21 | - | expression tag |
| Ser -20 | - | expression tag |
| His -19 | - | expression tag |
| Pro -18 | - | expression tag |
| Gln -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Glu -15 | - | expression tag |
| Lys -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Asn -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 183701.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 323.6 | |
| All* | Total formula weight | 184024.6 |
