4CEM
Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | REGULATOR OF NONSENSE TRANSCRIPTS 2 | polymer | 370 | 42965.9 | 2 | UniProt (Q9HAU5) Pfam (PF02854) | HOMO SAPIENS (HUMAN) | NONSENSE MRNA REDUCING FACTOR 2, UP-FRAMESHIFT SUPPRESSOR 2 HOMOLOG, HUPF2, UPF2 |
| 2 | C, D (A, B) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 121 - 486 (UniProt: Q9HAU5)
| PDB | External Database | Details |
|---|---|---|
| Gly 117 | - | expression tag |
| Ala 118 | - | expression tag |
| Mse 119 | - | expression tag |
| Gly 120 | - | expression tag |
| Ile 168 | Leu 168 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85931.7 | |
| All* | Total formula weight | 85931.7 |
