4CD0
Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ALK TYROSINE KINASE RECEPTOR | polymer | 342 | 38614.2 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE, CD246 |
2 | A | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | non-polymer | 472.5 | 1 | Chemie (AWJ) | |||
3 | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
PDB | External Database | Details |
---|---|---|
Met 1070 | - | expression tag |
Ala 1071 | - | expression tag |
His 1072 | - | expression tag |
His 1073 | - | expression tag |
His 1074 | - | expression tag |
His 1075 | - | expression tag |
His 1076 | - | expression tag |
His 1077 | - | expression tag |
Asp 1078 | - | expression tag |
Tyr 1079 | - | expression tag |
Gly 1080 | - | expression tag |
Ile 1081 | - | expression tag |
Pro 1082 | - | expression tag |
Thr 1083 | - | expression tag |
Thr 1084 | - | expression tag |
Glu 1085 | - | expression tag |
Asn 1086 | - | expression tag |
Leu 1087 | - | expression tag |
Tyr 1088 | - | expression tag |
Phe 1089 | - | expression tag |
Gln 1090 | - | expression tag |
Gly 1091 | - | expression tag |
Ser 1092 | - | expression tag |
Met 1196 | Leu 1196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38614.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 472.5 | |
All* | Total formula weight | 39086.7 |