4C3Z
Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 | polymer | 266 | 29032.8 | 1 | UniProt (P33527) Pfam (PF00005) | HOMO SAPIENS (HUMAN) | ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 1, LEUKOTRIENE C(4) TRANSPORTER, LTC4 TRANSPORTER, NUCLEOTIDE BINDING DOMAIN 1 |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | H (A) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 628 - 881 (UniProt: P33527)
| PDB | External Database | Details |
|---|---|---|
| Met 616 | - | expression tag |
| Ala 617 | - | expression tag |
| Arg 618 | - | expression tag |
| Ile 619 | - | expression tag |
| His 620 | - | expression tag |
| His 621 | - | expression tag |
| His 622 | - | expression tag |
| His 623 | - | expression tag |
| His 624 | - | expression tag |
| His 625 | - | expression tag |
| Gly 626 | - | expression tag |
| Ser 627 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29032.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 576.4 | |
| All* | Total formula weight | 29609.2 |
