4C37
PKA-S6K1 Chimera with compound 21a (CCT196539) bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 40948.7 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | BOS TAURUS (BOVINE) | PKA C-ALPHA |
2 | I | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 20 | 2226.4 | 1 | UniProt (Q3SX13) In PDB | BOS TAURUS | PKI-ALPHA |
3 | A | 4-(6-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine | non-polymer | 309.1 | 1 | Chemie (Z21) | |||
4 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
5 | water | water | 18.0 | 556 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P00517)
PDB | External Database | Details |
---|---|---|
Tyr 54 | Phe 55 | engineered mutation |
Leu 120 | Met 121 | engineered mutation |
Leu 123 | Val 124 | engineered mutation |
Met 173 | Leu 174 | engineered mutation |
Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43175.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 427.3 | |
All* | Total formula weight | 43602.4 |