4C35
PKA-S6K1 Chimera with compound 1 (NU1085) bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 41028.6 | 1 | UniProt (P00517) Pfam (PF00069) | BOS TAURUS (BOVINE) | PKA C-ALPHA |
| 2 | B (I) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 18 | 1973.2 | 1 | UniProt (Q3SX13) | BOS TAURUS | PKI-ALPHA |
| 3 | C (A) | 2-(4-hydroxyphenyl)-1H-benzimidazole-4-carboxamide | non-polymer | 253.3 | 1 | Chemie (NU3) | |||
| 4 | D (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 5 | E, F (A, I) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Tyr 54 | Phe 55 | engineered mutation |
| Leu 120 | Met 121 | engineered mutation |
| Leu 123 | Val 124 | engineered mutation |
| Met 173 | Leu 174 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43001.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 371.4 | |
| All* | Total formula weight | 43373.2 |
