4C2V

Aurora B kinase in complex with the specific inhibitor Barasertib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	AURORA KINASE B-A	polymer	285	33650.9	2	UniProt (Q6DE08) Pfam (PF00069)	XENOPUS LAEVIS (AFRICAN CLAWED FROG)	AURORA/IPL1-RELATED KINASE 2-A, AIRK2-A, XAIRK2-A, SERINE/THREONINE-PROTEIN KINASE 12-A, SERINE/THREONINE-PROTEIN KINASE AURORA-B-A, XAURORA-B
2	C, D (C, D)	INNER CENTROMERE PROTEIN A	polymer	44	5073.8	2	UniProt (O13024) Pfam (PF03941)	XENOPUS LAEVIS (AFRICAN CLAWED FROG)	XL-INCENP, XINC, XINCENP, MITOTIC PHOSPHOPROTEIN 130
3	E, F (A, B)	2-[5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-3-yl]-N-(3-fluorophenyl)ethanamide	non-polymer		507.6	2	Chemie (YJA)
4	G, H, I, J (A, B, C, D)	water	water		18.0	595	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	77449.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1015.1
All*	Total formula weight	78464.5

*Water molecules are not included.