4C2K

Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	3-KETOACYL-COA THIOLASE, MITOCHONDRIAL	polymer	417	44145.4	4	UniProt (P42765) Pfam (PF00108) Pfam (PF02803)	HOMO SAPIENS (HUMAN)	ACETYL-COA ACYLTRANSFERASE, BETA-KETOTHIOLASE, MITOCHONDRIAL 3-OXOACYL-COA THIOLASE, T1,3-KETOACYL-COA THIOLASE
2	AA, BA, CA, E, F... (D, A, B, C)	1,2-ETHANEDIOL	non-polymer		62.1	21	Chemie (EDO)
3	H (A)	2,3-DIHYDROXY-1,4-DITHIOBUTANE	non-polymer		154.3	1	Chemie (DTT)
4	DA, I, O, P (D, A, B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	4	Chemie (MES)
5	EA, FA, GA, HA (A, B, C, D)	water	water		18.0	488	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 397 (UniProt: P42765)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176581.7
Non-Polymers*	Number of molecules	26
	Total formula weight	2238.6
All*	Total formula weight	178820.3

*Water molecules are not included.