4C29
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | VON WILLEBRAND FACTOR | polymer | 215 | 24706.7 | 2 | UniProt (P04275) Pfam (PF00092) | HOMO SAPIENS (HUMAN) | VWF, VON WILLEBRAND ANTIGEN 2, VON WILLEBRAND ANTIGEN II |
| 2 | C (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 3 | D, E, H, I (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 4 | F, G, J (A, B) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A, B: 1264 - 1471 (UniProt: P04275)
| PDB | External Database | Details |
|---|---|---|
| Met 1263 | - | expression tag |
| His 1472 | - | expression tag |
| His 1473 | - | expression tag |
| His 1474 | - | expression tag |
| His 1475 | - | expression tag |
| His 1476 | - | expression tag |
| His 1477 | - | expression tag |
| Cys 1271 | Tyr 1271 | engineered mutation |
| Arg 1272 | Cys 1272 | engineered mutation |
| Ala 1381 | Thr 1381 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49413.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 603.8 | |
| All* | Total formula weight | 50017.1 |
