4BZN
Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE PIM-1 | polymer | 314 | 35835.7 | 1 | UniProt (P11309) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | PROTO-ONCOGENE SERINE THREONINE-PROTEIN KINASE PIM-1 |
| 2 | B (A) | N-(2,2-dimethylpropyl)-2-[1-oxo-7-(thiophen-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide | non-polymer | 345.5 | 1 | Chemie (UGX) | |||
| 3 | C (A) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A: 2 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35835.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 345.5 | |
| All* | Total formula weight | 36181.2 |
