4BZN
Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | SERINE/THREONINE-PROTEIN KINASE PIM-1 | polymer | 314 | 35835.7 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | PROTO-ONCOGENE SERINE THREONINE-PROTEIN KINASE PIM-1 |
2 | A | N-(2,2-dimethylpropyl)-2-[1-oxo-7-(thiophen-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide | non-polymer | 345.5 | 1 | Chemie (UGX) | |||
3 | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A: 2 - 313 (UniProt: P11309)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35835.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 345.5 | |
All* | Total formula weight | 36181.2 |