4BZ9
Crystal structure of Schistosoma mansoni HDAC8 complexed with J1075
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | HISTONE DEACETYLASE 8 | polymer | 446 | 50444.9 | 4 | UniProt (A5H660) Pfam (PF00850) In PDB | SCHISTOSOMA MANSONI | |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | D, A, B, C | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | D, A, B, C | 3-chlorobenzothiophene-2-carbohydroxamic acid | non-polymer | 227.7 | 8 | Chemie (KMY) | |||
| 5 | D, A, C | DIMETHYLFORMAMIDE | non-polymer | 73.1 | 6 | Chemie (DMF) | |||
| 6 | D, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 632 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 440 (UniProt: A5H660)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Leu 443 | - | expression tag |
| Val 444 | - | expression tag |
| Pro 445 | - | expression tag |
| Arg 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 201779.5 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3018.5 | |
| All* | Total formula weight | 204798.0 |
