4BZ7
Crystal structure of Schistosoma mansoni HDAC8 complexed with M344
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HISTONE DEACETYLASE 8 | polymer | 446 | 50444.9 | 4 | UniProt (A5H660) Pfam (PF00850) | SCHISTOSOMA MANSONI | |
| 2 | DA, E, M, U (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | EA, F, FA, G, N... (D, A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | GA, H, HA, I, P... (D, A, B, C) | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 8 | Chemie (B3N) | |||
| 5 | AA, BA, CA, IA, J... (C, D, A, B) | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) | |||
| 6 | MA, NA, OA, PA (A, B, C, D) | water | water | 18.0 | 1171 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 440 (UniProt: A5H660)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Leu 443 | - | expression tag |
| Val 444 | - | expression tag |
| Pro 445 | - | expression tag |
| Arg 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 201779.5 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 4322.8 | |
| All* | Total formula weight | 206102.3 |
