4BZ6
Crystal structure of Schistosoma mansoni HDAC8 complexed with SAHA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HISTONE DEACETYLASE 8 | polymer | 446 | 50444.9 | 4 | UniProt (A5H660) Pfam (PF00850) | SCHISTOSOMA MANSONI | |
| 2 | E, J, Q, W (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, G, K, L, R... (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | H, M, T, Z (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | AA, I, P, V (D, A, B, C) | OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE | non-polymer | 264.3 | 4 | Chemie (SHH) | |||
| 6 | N, O, U (B, C) | DIMETHYLFORMAMIDE | non-polymer | 73.1 | 3 | Chemie (DMF) | |||
| 7 | BA, CA, DA, EA (A, B, C, D) | water | water | 18.0 | 926 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 440 (UniProt: A5H660)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Leu 443 | - | expression tag |
| Val 444 | - | expression tag |
| Pro 445 | - | expression tag |
| Arg 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 201779.5 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2219.4 | |
| All* | Total formula weight | 203998.9 |
