4BVF
CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL | polymer | 284 | 31484.2 | 1 | UniProt (Q9NTG7) Pfam (PF02146) | HOMO SAPIENS (HUMAN) | SIRT3, HSIRT3, REGULATORY PROTEIN SIR2 HOMOLOG 3, SIR2-LIKE PROTEIN 3 |
| 2 | B (B) | ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL | polymer | 10 | 1805.9 | 1 | UniProt (Q9NUB1) | HOMO SAPIENS | THIO-ACETYL-LYSINE ACS2-PEPTIDE, ACETATE--COA LIGASE 2, ACET ACECS2, ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 1 |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33290.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 127.5 | |
| All* | Total formula weight | 33417.6 |
