4BV3
CRYSTAL STRUCTURE OF SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL | polymer | 284 | 31484.2 | 1 | UniProt (Q9NTG7) Pfam (PF02146) | HOMO SAPIENS (HUMAN) | HSIRT3, REGULATORY PROTEIN SIR2 HOMOLOG 3, SIR2-LIKE PROTEIN 3, SIRT3 |
| 2 | B (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 3 | C (A) | ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 559.3 | 1 | Chemie (APR) | |||
| 4 | D (A) | (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide | non-polymer | 248.7 | 1 | Chemie (OCZ) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (A) | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
| 7 | G, H (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | I (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | J (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | K (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31484.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1841.5 | |
| All* | Total formula weight | 33325.7 |
