4BQX
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | EGL NINE HOMOLOG 1 | polymer | 252 | 28096.9 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | HOMO SAPIENS (HUMAN) | HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2, HIF-PH2, HIF-PROLYL HYDROXYLASE 2, HPH-2, PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2, PHD2, SM-20 |
2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
3 | A | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 280.7 | 1 | Chemie (UN9) | |||
4 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A: 181 - 426 (UniProt: Q9GZT9)
PDB | External Database | Details |
---|---|---|
Gly 175 | - | expression tag |
Ser 176 | - | expression tag |
His 177 | - | expression tag |
Met 178 | - | expression tag |
Ala 179 | - | expression tag |
Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28096.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 335.6 | |
All* | Total formula weight | 28432.5 |