4BQ6

Crystal structure of the RGMB-NEO1 complex form 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NEOGENIN	polymer	264	29221.8	2	UniProt (P97798) Pfam (PF00041)	MUS MUSCULUS (HOUSE MOUSE)
2	C, E (C, E)	RGM DOMAIN FAMILY MEMBER B	polymer	122	13318.7	2	UniProt (Q6NW40) Pfam (PF06535)	HOMO SAPIENS (HUMAN)	REPULSIVE GUIDANCE MOLECULE B, DRG11-RESPONSIVE AXONAL GUIDANCE AND OUTGROWTH OF NEURITE, DRAGON
3	D, F (D, F)	RGM DOMAIN FAMILY MEMBER B	polymer	251	27945.4	2	UniProt (Q6NW40) Pfam (PF06535) Pfam (PF06534)	HOMO SAPIENS (HUMAN)	REPULSIVE GUIDANCE MOLECULE B, DRG11-RESPONSIVE AXONAL GUIDANCE AND OUTGROWTH OF NEURITE, DRAGON
4	G, H (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	I, J, K, L (A, B, C, D)	water	water		18.0	329	Chemie (HOH)

Sequence modifications

A, B: 883 - 1133 (UniProt: P97798)

PDB	External Database	Details
Glu 880	-	expression tag
Thr 881	-	expression tag
Gly 882	-	expression tag
Asn 1134	-	expression tag
Gly 1135	-	expression tag
Thr 1136	-	expression tag
Lys 1137	-	expression tag
His 1138	-	expression tag
His 1139	-	expression tag
His 1140	-	expression tag
His 1141	-	expression tag
His 1142	-	expression tag
His 1143	-	expression tag

C, E: 50 - 168 (UniProt: Q6NW40)

PDB	External Database	Details
Glu 47	-	expression tag
Thr 48	-	expression tag
Gly 49	-	expression tag

D, F: 169 - 410 (UniProt: Q6NW40)

PDB	External Database	Details
Gly 411	-	expression tag
Thr 412	-	expression tag
Lys 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag
His 417	-	expression tag
His 418	-	expression tag
His 419	-	expression tag
Gly 225	Glu 225	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	140971.8
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	141414.2

*Water molecules are not included.